I talk about allele-specific expression: why it arises and how it can be
reliably detected.

      

      
      Sections:


  The biology of allele-specific expression (2:17)
  Detecting allele-specific expression with RNA-seq (7:46)
  Mapping and sequencing biases (16:39)
  The experiment in yeast (19:47)
  Statistical models (21:44)


Links:


  A powerful and flexible statistical framework for testing hypotheses of
allele-specific gene expression from RNA-seq data
    
      Supplemenal information
    
  
  Effect of read-mapping biases on detecting allele-specific expression from RNA-sequencing data
  The talk by John Marioni
  The blog post explaining the RSEM model


The biology of allele-specific expression

Detecting allele-specific expression with RNA-seq

#7 Metagenomics and Kraken

A podcast about computational biology, bioinformatics, and next generation sequencing.