The BioCentury Show
The BioCentury Show
BioCentury
Ep. 111 - McGill's Angela Genge on why ALS drug development is turning a corner
36 minutes Posted Jun 12, 2026 at 11:00 pm.
Introduction
ALS Mechanistic Diversity
Trial Design Challenges
Biomarker Toolkit Update
ALS Pharma & SOD1
0:00
36:55
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Show notes
ALS drug development has long been hampered by heterogeneity, but Angela Genge — neurologist at McGill University and CMO of AL-S Pharma — argues the field is getting closer to making that heterogeneity tractable. On The BioCentury Show, Genge discusses progress in pathway prioritization, progression-rate prediction, and endpoint standardization with BioCentury's Selina Koch. On the biology side, Genge expects the field to converge on a small number of high-priority pathways. SOD1 is the firs...