In this ANZUP conference highlight, Craig Gedye chats to Carole Harris, Patti Bastik & Antoinette Fontela, the investigators for the KEYPAD trial. They chat about what it is like to be involved in a clinical trial for the doctor and the patients, the barriers faced to running a successful clinical trial, the KEYPAD study investigating the addition of immuno-oncology agents plus denosumab, and the techniques they have used to improve the success of their trials.