As the COVID-19 pandemic swept across the United States, we began to hear case reports of an unusual inflammatory syndrome showing up in kids who had been infected with or exposed to the COVID-19 virus. With symptoms that are similar to Kawasaki Disease, with a few distinct differences, our Children’s Immunologist Tamara Pozos, MD, and Emergency Room physician Kelly Robert Bergmann, DO, MS, discuss Dr. Gabi Hester the presenting signs and symptoms and the diagnostic workup of what we now know as MIS-C.