In Part 2 of Thinking Thoracic's annual review of the year's most influential thoracic oncology research, Drs. Jeff Yang and Linda Martin examine practice-changing studies in perioperative care, lung cancer treatment, and multidisciplinary cancer management.The discussion covers emerging evidence on cryoanalgesia, preoperative fasting, targeted therapies for EGFR-mutated lung cancer, and other key clinical trials and consensus recommendations that are influencing patient care today.