In John Steinbeck's Great Depression novel Of Mice and Men, Chapter 4 is dedicated to the interaction of four marginalized characters: a man-child with superhuman strength, an old man with one hand, a black man with a crooked spine, and a woman in an unhappy marriage. This episode is a microcosm of the book's overall themes. 

Steinbeck, John. Of Mice and Men. New York: Penguin, 1993.