Anchors Carl Quintanilla, David Faber and Jim Cramer started the show with Oracle’s CEO changes. The company promoted executives Clay Magouyrk and Mike Sicilia as new CEOs, while current CEO Safra Catz will serve as executive vice chair on the company board. The desk also spoke First on CNBC with T-Mobile’s incoming and outgoing CEOs about their own leadership changes. After the opening bells, the anchors also discussed Pfizer’s deal for weight loss biotech company Metsera in a transaction valued up to $7.3 billion.  <a href="https://urldefense.com/v3/__https:/www.cnbc.com/squawk-on-the-street-disclaimer/__;!!HqJSLGM!uCnRzL8sw0zDv24y-5sOIFUC0pgExA9JnNMmwWkZd5mUIQJQpFQRdlNhw1zMYFFYNdQOPGVM3L-r8djVB-JZ4_RPwpfewNor$">Squawk on the Street Disclaimer</a> Hosted by Simplecast, an AdsWizz company. See <a href="https://pcm.adswizz.com">pcm.adswizz.com</a> for information about our collection and use of personal data for advertising.

SOTS 2nd Hour: Fed-spectations, Coreweave CEO Talks Demand, & Oracle: Buy, Sell, or Hold? 9/22/25

CNBC’s “Squawk on the Street” with Carl Quintanilla, Jim Cramer, David Faber and Sara Eisen is broadcast from the floor of the New York Stock Exchange, on site at the opening bell with the up-to-the-minute news investors need to know and interviews with the most influential CEOs and greatest market minds.