A conversation with Dick Tsien on moving from cardiac physiology to LTP in a half-dozen years, conformational signaling by channels, and being a physiologist in the UK when Hodgkin, Huxley, and Katz were all doing experiments Download PDF transcript Key words: cardiac physiology, neuroscience, LTP, calcium channels, N-type channels, Denis Noble, Alan Hodgkin
Sep 28, 2015
A conversation with Henry Lester on nicotinic acetylcholine receptors, inside-out pharmacology, teaching MOOCs, and Richard Feynman’s thoughts about single-channel recording. Download PDF transcript Key words: nicotine, nAChR, nicotinic receptor, inside-out pharmacology, MOOCs
Aug 24, 2015
A conversation with Don Bers on calcium signaling and compartmentation in cardiac myocytes. Download PDF transcript Key words: calcium, cardiomyocytes, cardiac contractility, calcium compartmentation, arrhythmias, CaM kinase
Jul 27, 2015
A conversation with Eduardo Ríos on post-Hodgkin thought, the voltage sensor in EC coupling, calcium sparks, and the university system in Uruguay. Download PDF transcript Key words: dihydropyridine receptor, ryanodine receptor, calcium sparks, cardiac muscle, skeletal muscle, calcium sparks, excitation-contraction coupling, calsequestrin
May 25, 2015
A conversation with Paul Greengard on “hormonal” communication between nerve cells, the biochemical bases by which antidepressants work, and the Pearl Meister Greengard Prize for outstanding women in biomedical research. Download PDF transcript Key words: second messengers, protein phosphorylation, slow synaptic transmission, protein kinases, cGMP, cAMP, synapsin I, serotonin, dopamine, p11, annexin A2, SMARCA3
Apr 27, 2015
A conversation with Chris Miller on channels, transporters, radical reductionism, and trusting your sense of scientific aesthetics. Download PDF Transcript Key words: ion channels, ion transporters, biophysics, ClC, chloride, fluoride, Fluc, lipid bilayers
Mar 30, 2015
A conversation with Richard Lewis on electrical resonance in hair cells, channels and signals in T cells, papayas in the lab, and following your nose. Download PDF transcript Key words: calcium, T cell, Hair cell, Papain, Orai, STIM, CRAC channels
Feb 23, 2015
A conversation with Barbara Ehrlich on calcium signaling, interpreting Truth, and what’s wrong with green apple-wasabi sorbet. Download PDF transcript Key words: calcium, IP3 receptor, ryanodine receptor, polycystin-2, paramecium, molecular hermeneutics, taxol, lithium, NCS-1, peripheral neuropathy
Jan 26, 2015
A conversation with David Clapham, on where scientific curiosity can take you. Download PDF transcript Key words: calcium, sperm, mitochondria, cilia, TRPM7, GPCRs, CRAC, noise analysis, patch clamp, channels
Dec 29, 2014
A conversation with Tullio Pozzan on calcium compartmentation and dynamics, and signaling between the mitochondria and the ER. Download PDF transcript Key words: calcium, cAMP, mitochondria, endoplamic reticulum, calcium indicators
Nov 24, 2014
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