Cells use complex networks to handle metabolic, regulatory and signaling operations. Assuring robust operations of these networks is, literally, a matter of life and death. These networks, furthermore, must be able to adapt to significant changes in their operating environment; e.g., in the absence of glucose a bacteria may need to reconfigure its networks to process lactose. Cellular networks thus face similar challenges of managing failures and configuration changes as communication networks. Unlike communication networks, however, these operations management functions must be integrated into the networks design. This presentation will consider some of the architectural fundamentals of genomic networks from the perspective of integrated network management.