What puts the quasi in quasi-experimental designs? What makes a quasi-experimental study different than a “real” experiment? Ever wondered about the difference between regression discontinuity, difference-in-differences, and synthetic control methods? Dr. Tarik Benmarnhia joins us on this episode of SERious Epidemiology to talk us through a range of quasi-experimental designs. He makes a strong case for why we should integrate these designs in a variety of settings in epidemiology ranging from public health policy to clinical epidemiologyAfter listening to this podcast, if you are interested in learning more about quasi-experimental designs, you can check out some of the resources below:Abadie A, Diamond A, Hainmueller J. (2010) Synthetic Control Methods for Comparative Case Studies: Estimating the Effect of California’s Tobacco Control Program, Journal of the American Statistical Association, Chen H, Li Q, Kaufman JS, Wang J, Copes R, Su Y, Benmarhnia T. Effect of air quality alerts on human health: a regression discontinuity analysis in Toronto, Canada. Lancet Planet Health. 2018 Jan;2(1):e19-e26. doi: 10.1016/S2542-5196(17)30185-7. Epub 2018 Jan 9. PMID: 29615204.Auger N, Kuehne E, Goneau M, Daniel M. Preterm birth during an extreme weather event in Québec, Canada: a “natural experiment”. Matern Child Health J. 2011 Oct;15(7):1088-96. doi: 10.1007/s10995-010-0645-0. PMID: 20640493.Hernán MA, Robins JM. Instruments for causal inference: an epidemiologist’s dream? Epidemiology. 2006 Jul;17(4):360-72. doi: 10.1097/01.ede.0000222409.00878.37. Erratum in: Epidemiology. 2014 Jan;25(1):164. PMID: 16755261.Courtemanche, C., Marton, J., Ukert, B., Yelowitz, A. and Zapata, D. (2017), Early Impacts of the Affordable Care Act on Health Insurance Coverage in Medicaid Expansion and Non‐Expansion States. J. Pol. Anal. Manage., 36: 178-210. https://doi.org/10.1002/pam.21961Bor J, Fox MP, Rosen S, Venkataramani A, Tanser F, Pillay D, Bärnighausen T. Treatment eligibility and retention in clinical HIV care: A regression discontinuity study in South Africa. PLoS Med. 2017 Nov 28;14(11):e1002463. doi: 10.1371/journal.pmed.1002463. PMID: 29182641; PMCID: PMC5705070.Bor J, Moscoe E, Mutevedzi P, Newell ML, Bärnighausen T. Regression discontinuity designs in epidemiology: causal inference without randomized trials. Epidemiology. 2014 Sep;25(5):729-37. doi: 10.1097/EDE.0000000000000138. PMID: 25061922; PMCID: PMC4162343.Elder TE. The importance of relative standards in ADHD diagnoses: evidence based on exact birth dates. J Health Econ. 2010;29(5):641-656. doi:10.1016/j.jhealeco.2010.06.003Smith LM, Kaufman JS, Strumpf EC, Lévesque LE. Effect of human papillomavirus (HPV) vaccination on clinical indicators of sexual behaviour among adolescent girls: the Ontario Grade 8 HPV Vaccine Cohort Study. CMAJ. 2015;187(2):E74-E81. doi:10.1503/cmaj.140900