Rx for Biotech
Rx for Biotech
Podcast Host Chris Leidli
Can Stem Cell Therapy Heal Chronic Back Pain? The Future of Regenerative Medicine
32 minutes Posted Jul 23, 2026 at 1:21 pm.
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Can stem cell therapy help repair damaged spinal discs instead of simply masking pain?
Millions of people suffer from chronic low back pain and degenerative disc disease, yet today's standard treatments often focus on symptom management through pain medications, steroid injections, or invasive surgery. But what if regenerative medicine could change that?
In this episode of Rx for Biotech, host Chris Leidli sits down with Lance Alstodt, CEO of BioRestorative Therapies, to explore how the company is developing next-generation regenerative medicine platforms designed to restore function—not just relieve symptoms.
Lance discusses BioRestorative's lead clinical program, BRTX-100, an investigational autologous stem cell therapy currently in Phase 2 clinical development for chronic lumbar disc disease. The conversation explores how stem cells are expanded using the company's proprietary hypoxic manufacturing process before being injected directly into damaged spinal discs in an effort to promote tissue repair.
The discussion also looks beyond spine health to BioRestorative's ThermoStem® platform, which is investigating the potential of brown adipose (brown fat) stem cells to improve metabolic health and complement GLP-1 weight-loss therapies. Finally, Lance explains how the company's expertise in stem cells and exosome biology is also being applied to next-generation skincare and regenerative aesthetics.
In this episode you'll learn:
• Why chronic low back pain remains one of healthcare's largest unmet needs
• How regenerative medicine differs from traditional pain management
• The science behind BRTX-100 and autologous stem cell therapy
• Why BioRestorative uses proprietary hypoxic cell expansion
• Current Phase 2 clinical trial progress and safety observations
• The future of regenerative medicine for orthopedic diseases
• How brown fat stem cells could complement GLP-1 therapies
• What exosomes are—and why not all exosomes are created equal
• The difference between FDA-regulated cell therapies and many commercial regenerative medicine clinics
• BioRestorative's long-term vision for restoring function instead of simply managing symptoms
Whether you're a patient living with chronic back pain, a healthcare professional, an investor, or simply interested in the future of regenerative medicine, this episode provides an inside look at one of the most exciting areas of biotechnology.