In this episode of Raising Biotech, Surani Fernando speaks with eGenesis CEO Mike Curtis on its mission to create pig donor organs for humans waiting for a transplant. The company has raised $263 million over the last 6 years and is now raising further funds to start human clinical trials.Surani speaks to Mike about the company's history overcoming past Xenotransplantation challenges and using CRISPR Cas9 to finalize their platform -- which conducts 69 edits in the pig genome for optimal compatibility and safety in humans. After recent data (Nature) showed a maximum survival of a monkey surviving with a pig kidney for over 2 years, the company is talking to regulators to enter clinical trials and in parallel is talking to investors and potential partners to take its programs forward. As the company enters unchartered territory, all future strategic business options are on the table. Dr Adam Griesemer, associate professor of surgery at Grossman School of Medicine, NYU Langone Health, gives his take on the unmet need and progress of Xenotransplanation and eGenesis' scientific thesis of 69 gene edits. He also discusses the academic debate around the number of genetic edits needed and logistical considerations for implementing and scaling the availability of pig donor organs for human transplantation.Timestamps:For any comments, questions, feedback or suggestions you can connect directly with Surani Fernando on LinkedIn or email: [email protected]Music composed by: Yrii Semchyshyn (Coma Media) Hosted on Acast. See acast.com/privacy for more information.