Show notes
Welcome to the Olink® Proteomics in Proximity podcast! Below are some useful resources mentioned in this episode: UK Biobank Pharma Proteomics Project (UKB-PPP), one of the world’s largest scientific studies of blood protein biomarkers conducted to date. https://www.ukbiobank.ac.uk/learn-more-about-uk-biobank/news/uk-biobank-launches-one-of-the-largest-scientific-studies Research articles and newsUK Biobank Pharma Proteomics Project Full Cohort Study: Thermo Fisher Scientific’s Olink Platform Selected for World’s Largest Human Proteome Studyhttps://ir.thermofisher.com/investors/news-events/news/news-details/2025/Thermo-Fisher-Scientifics-Olink-Platform-Selected-for-Worlds-Largest-Human-Proteome-Study/default.aspxParabiosis Conboy et al (2005) Rejuvenation of aged progenitor cells by exposure to a young systemic environment. Nature 433: 760-764. https://www.nature.com/articles/nature03260Villeda et al. (2011). The ageing systemic milieu negatively regulates neurogenesis and cognitive function. Nature 477, 90–94 https://doi.org/10.1038/nature10357Organ Aging/Ageing Clock Publications leveraging Olink ProteomicsOh, H.SH et al. (2025). Plasma proteomics links brain and immune system aging with healthspan and longevity. Nat Med 31, 2703–2711. https://doi.org/10.1038/s41591-025-03798-1Goeminne et al (2025). Plasma protein-based organ-specific aging and mortality models unveil diseases as accelerated aging of organismal systems Cell Metabolism, 37, 205-222.e6https://www.cell.com/cell-metabolism/fulltext/S1550-4131(24)00401-7Argentieri, M.A et al. (2024). Proteomic aging clock predicts mortality and risk of common age-related diseases in diverse populations. Nat Med 30, 2450–2460. https://doi.org/10.1038/s41591-024-03164-7Young blood factors infused into young miceVilleda et al (2014). Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice. Nature Medicine. 20:659-663. https://www.nature.com/articles/nm.3569Single cell work with Stephen QuakePálovics et al (2022). Molecular hallmarks of heterochronic parabiosis at single-cell resolution. Nature 603:309-314. https://www.nature.com/articles/s41586-022-04461-2Andrew Yang, Gladstone Institute labeling of hundreds of endogenous plasma proteinsYang et al (2020). Physiological blood-brain transport is impaired with age by a shift in transcytosis. Nature 583: 425-430. https://www.nature.com/articles/s41586-020-2453-zEric Topol episode with Tony on Ground Truthshttps://erictopol.substack.com/p/tony-wyss-coray-the-science-of-agingMike Snyder’s team (Stanford) and the concept of AgeotypesAhadi S et al. (2020). Personal aging markers and ageotypes revealed by deep longitudinal profiling. Nature Medicine. 2020;26:83–90. https://www.nature.com/articles/s41591-019-0719-5Preprint ahead of Nature Medicine paper Tony references coming out weeks after podcast episodeDing et al (2026; preprint). Cellular Aging Signatures in the Plasma Proteome Record Human Health and Disease. bioRxiv https://www.biorxiv.org/content/10.64898/2026.02.10.704909v1Vero Biosciences: Founded with Tony where a consumer can have blood measured, which organs show accelerated aging with clinician input into potential interventions. https://www.verobioscience.com/Teal Rise: Founded with Tony, partnering with Olink that has collected a large database to drive model building across diseases and prediction. https://tealrise.com/Heike A. Bischoff-Ferrari and the Do-Health Trial:Bischoff-Ferrari et al (2025). Individual and additive effects of vitamin D, omega-3, and exercise on DNA methylation clocks of biological aging in older adults in the Do-Health trial. Nature Aging. 5: 376-385. https://www.nature.com/articles/s43587-024-00793-ySubscribe to the podcast on your favorite player or app:Apple Podcasts: https://apple.co/3T0YbSm Spotify Podcasts: https://open.spotify.com/show/2sZ2wxOqI4b4vSngkajLs8Amazon Music: https://music.amazon.com/podcasts/d97ace94-f02b-4b37-9532-799548ef2840/proteomics-in-proximityPodcast Addict: https://podcastaddict.com/podcast/proteomics-in-proximity/4098296Deezer: https://www.deezer.com/us/show/5178787Proteomics in Proximity refers to the principle underlying Olink technology called the Proximity Extension Assay (PEA). More information about the assay and how it works can be found here: https://bit.ly/3Rt7YiY Host: Cindy LawleyCo-host: Sarantis ChlamydasExecutive Producer: Cindy LawleyEditor: Fredrik Hamfelt, PhosworksProject Manager: Eva Kellerman, PhosworksFor any questions regarding information Olink Proteomics, please email us at [email protected] or visit our website: https://www.olink.com/
