In this podcast, Charles Flexner, MD, speaks about a clinician's approach to managing a patient with HIV and limited treatment options, including choosing a new treatment regimen, understanding the underlying processes that caused previous treatment failures, and what is on the horizon for research in the management of patients with HIV and limited treatment options. Dr Flexner also participated in a symposium on these topics titled "Managing HIV Patients With Limited Treatment Options" at IDWeek 2022.