Physik - Open Access LMU - Teil 01/02
Physik - Open Access LMU - Teil 01/02
Ludwig-Maximilians-Universität München
Microtubule Length Regulation by Molecular Motors
1 seconds Posted Jun 1, 2012 at 11:00 am.
0:00
0:01
Download MP3
Show notes
Length regulation of microtubules (MTs) is essential for many cellular processes. Molecular motors like kinesin-8, which move along MTs and also act as depolymerases, are known as key players in MT dynamics. However, the regulatory mechanisms of length control remain elusive. Here, we investigate a stochastic model accounting for the interplay between polymerization kinetics and motor-induced depolymerization. We determine the dependence of MT length and variance on rate constants and motor concentration. Moreover, our analyses reveal how collective phenomena lead to a well-defined MT length.