Many American Indian/Alaska Native (AI/AN) communities experience high rates of health inequities including tobacco-related health conditions, alcohol and substance use disorders, suicide deaths, and more recently, negative impacts of the COVID-19 global pandemic. These health inequities have catastrophic mental health and public health impacts; yet, these research areas remain largely understudied among AI/AN populations. In this episode, Meghan Robinson speaks with Dr. Ashley Cole to learn more about existing prevention and intervention efforts to improve the health of AI/AN communities.