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We review the 5-year update of CheckMate 227 and the POSEIDON to generate the hypothesis that CLTA-4 inhibition has a role in PD-L1 negative metastatic NSCLC.CM 227 update: https://pubmed.ncbi.nlm.nih.gov/?term=36223558POSEIDON: https://pubmed.ncbi.nlm.nih.gov/?term=36327426Editorial: https://pubmed.ncbi.nlm.nih.gov/?term=36331243

