Professor Gerben Keijzers discuss critical themes in clinical practice, focusing on clinical reasoning, evidence-based practice, and traditional methods. They highlight the importance of understanding likelihood ratios, cognitive biases, and problem representation in diagnosis, alongside the effective use of clinical decision tools. The conversation underscores the value of incorporating patient perspectives into decision-making and balancing evidence with experience. Gerbern shares practical strategies to minimise biases and encourages clinicians to refine their decision-making styles while staying adaptable to patient needs. He emphasises the detective-like role of clinicians, combining reasoning with patient-personalised care. Website links discussed in show https://first10em.com/clinical-decision-rules/ https://onlinelibrary.wiley.com/doi/abs/10.1111/1742-6723.13126 Chapters