Neurology Minute
Neurology Minute
American Academy of Neurology
Efficacy and Safety of Cemdisiran siRNA in Myasthenia Gravis
3 minutes Posted Aug 12, 2026 at 8:30 am.
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Dr. Aaron S. Zelikovich discusses the phase 3 NIMBLE trial of cemdisiran, an siRNA targeting complement component 5, for the treatment of generalized myasthenia gravis.

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Vu T, Habib AA, Jacob S, et al. Efficacy and safety of cemdisiran siRNA in myasthenia gravis (NIMBLE): a double-blind, randomised, placebo-controlled, phase 3 trial. Lancet. 2026;407(10540):1712-1725. doi:10.1016/S0140-6736(26)00690-2