In this episode, board-certified neurologist Dr. David Perlmutter, author of Brain Defenders, reveals how your brain’s immune cells, the microglia, hold the key to preventing cognitive decline and neurodegenerative disease.
For decades, neurodegenerative research has fixated on amyloid plaques and tau tangles, treating the downstream smoke while ignoring the raging metabolic fire beneath. In this comprehensive masterclass, Dr. Perlmutter reveals why the real driver of brain aging lies within microglia, the brain's resident immune defenders. Under healthy conditions, microglia nurture synapses and clear debris. But when triggered by elevated blood glucose, gut dysbiosis, environmental air toxins, or lack of deep sleep, they flip into an aggressive, destructive phenotype that destroys brain connections. Dr. Perlmutter shares practical, evidence-based protocols to keep your microglia in their protective state: why a fasting glucose above 90 mg/dL poses hidden risks, how muscle-derived myokines cross the blood-brain barrier, the truth about adult hippocampal neurogenesis, and the exact supplement stack (including DHA, Akkermansia, Urolithin A, DHM, and rosmarinic acid) supported by peer-reviewed science.
🌐Links in this video
Dr Perlmutter's book Brain Defenders: Harness the Power of Your Immune Cells to Protect Your Brain for Life on Amazon https://amzn.to/4y4U77Y Dr Perlmutter's home page https://drperlmutter.com/
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