Drs Cross and Bainbridge discuss cannabis, safety issues, drug-drug interactions, potential liver toxicity, tolerance, and possible dependency for people living with MS.

Relevant disclosures can be found with the episode show notes on Medscape (https://www.medscape.com/viewarticle/977034). The topics and discussions are planned, produced, and reviewed independently of advertiser. This podcast is intended only for US healthcare professionals.

Resources

Cannabinoids in Medicine: Limitless Hope or Hype? https://www.medscape.com/viewarticle/973874

Medicinal Cannabis: History, Pharmacology, and Implications for the Acute Care Setting https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5312634/

Sativex Prescribing Information https://www.tga.gov.au/sites/default/files/auspar-nabiximols-130927-pi.pdf

Epidiolex Prescribing Information https://pp.jazzpharma.com/pi/epidiolex.en.USPI.pdf

Cannabinoid Poisoning Workup https://emedicine.medscape.com/article/833828-workup

Cannabis and Psychosis: Recent Epidemiological Findings Continuing the "Causality Debate" https://ajp.psychiatryonline.org/doi/10.1176/appi.ajp.2021.21111126

Cannabinoid Hyperemesis Syndrome https://www.ncbi.nlm.nih.gov/books/NBK549915/

Trial Evaluating Nabiximols Oromucosal Spray in Adult Participants With Multiple Sclerosis Spasticity https://investor.jazzpharma.com/news-releases/news-release-details/jazz-pharmaceuticals-announces-top-line-results-phase-3-trial