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Primary adrenal insufficiency (AI), also called Addison's disease, is a rare condition where the adrenal glands do not work properly and cannot make enough cortisol (a “stress” hormone). Usually, production of aldosterone and androgens (the two other types of steroid hormones made by the adrenal glands) is also low.   Secondary AI is the far more common type of AI. It results when the pituitary gland, a small gland near the brain, does not signal the adrenal glands to make cortisol. Production of aldosterone is normal in secondary AI.    The adrenal glands do not get “adrenal fatigue” or lose function because of mental or physical stress. True AI is a rare health problem. Only an endocrinologist, an expert in hormones, should diagnose AI using standard tests.