In this edition, Charles L. Raison, MD, explores how ketamine impacts depression. He also explains how weather and climate can be a metaphor for the brain. Dr. Raison is the Mary Sue and Mike Shannon Chair for Healthy Minds, Children & Families at the University of Wisconsin School of Human Ecology. After the conclusion to our discussion on ketamine, Dr. Renee Kohanski finds the psychiatric nuggets from the remarkable film, Three Identical Strangers.