This is the second episode in a series of podcasts following the 62nd American Society of Hematology (ASH) Annual Meeting and Exposition, on the topic of circulating tumor DNA (ctDNA) in the management of lymphoma. The Lymphoma hub asked Reid Merryman, Dana-Farber Cancer Institute, Boston, US, Can circulating tumor DNA (ctDNA) help inform on the suitability of autologous stem cell transplantation (auto-SCT) in patients with diffuse large B-cell lymphoma (DLBCL)?

Merryman firstly outlines a strategy for using ctDNA as a prognostic biomarker in patients with DLBCL undergoing auto-STC. Merryman provides supporting data from a study evaluating the prognostic value of ctDNA using an immunoglobulin-based next-generation sequencing technique in patients with DLBCL undergoing auto-STC. He highlights the poor 5-year progression-free survival in patients who were ctDNA-positive within an apheresis stem cell sample. He concludes by outlining the importance of ctDNA as a powerful predictor of relapse; in the future, this tool could be used to guide treatment in patients who are ctDNA-positive.

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