Live Longer World
Live Longer World
Aastha JS
#21 Selenium's Dual Role in Health & Aging in the Womb | Dr. Vadim Gladyshev
1 hour Posted May 10, 2022 at 2:10 pm.
Vadim Gladyshev Intro 
Live Longer World 
Selenium’s dual role in aging (the good, the bad, the ugly) 
Antagonistic Pleiotropy 
Selenium & Cancer 
Selenium Dosage (don’t get too much!) 
Reactive Oxygen Species, Antioxidants & Aging 
Fundamental basis of Aging 
Aging is damage 
Single cell Epigenetic Clocks 
Aging in the Womb 
Parent’s lifestyle for aging in embryo 
Rapamycin during development 
Other compounds 
Slowing Aging vs. Rejuvenation 
New projects being worked on 
Confidence level in extending lifespan within 30 years 
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Show notes
All platforms / Episode Show Notes: https://livelongerworld.substack.com/p/vgladyshev 
Dr. Vadim Gladyshev is a professor at Harvard Medical school and a Director of redox medicine at Brigham and Women’s hospital, where he runs his own lab.  We had a brilliant discussion which started off by talking about his work on selenium. Selenium is found is Brazil nuts and we discussed its connection to aging and cancer prevention, and also some of the harmful effects it can have. Dr. Gladyshev calls it the good, the bad, the ugly nature of selenium.   
Then, we discussed a fair bit on his theory of aging before and after development. Most people believe that the germline which is the reproductive cells do not age, but his lab’s work has shown how the germline does in fact age. On this point, his lab also has interesting results on how rapamycin during development extended lifespan in mice.  
It’s important to understand the basic science and understand more on the aging process in order to crack it. Dr. Gladyshev shares his views on this too and his research is certainly a step towards cracking the aging code. I hope you enjoy the conversation!  
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VADIM GLADYSHEV LINKS: 
Website: https://gladyshevlab.bwh.harvard.edu/2022 
Rapamycin During Development extends Lifespan: https://www.biorxiv.org/content/10.1101/2022.02.18.481092v1 
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Episode Show Notes: https://livelongerworld.substack.com/p/vgladyshev 
Live Longer World Season 1 Recap: https://livelongerworld.substack.com/p/season1 
Thanks for watching & if you enjoy the episode, let's spread the message on longevity.   
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Aging is universal. Let's unite in this fight. Stay in good health - Aastha.