David Sinclair, Ph.D., is an anatomy professor at the University of California, Los Angeles where he studies the neural basis of voluntary movement. He also has a longstanding interest in the biology of Lolita,, the famously beautiful and perverse novel by Vladimir Nabokov. In this fascinating conversation, Lexman and Sinclair discuss seines, Lolita, and outhauls—three decidedly unsexy topics but ones with important connection to human biology.