In this KER Cast installment, Dr. Victor Montori is joined by Dr. Isabelle Boutron, professor of epidemiology at the Université de Paris and head of the INSERM-METHODS team within the Centre of Research in Epidemiology and Statistics (CRESS). Dr. Boutron discusses her clinical and research background, including her experience as a post-doctoral scholar at Oxford; her interest in reducing waste in research design, conduct, and reporting; and the absolute necessity of clinical research that interrogates the world from the perspective of the patient.