When 2 in every 3 people with a musculoskeletal condition also have at least one other underlying health condition, it’s time for rehabilitation clinicians to up our game in understanding complex health needs. Thankfully, Professor Søren Skou is here to help. Who is best placed to help patients manage their complex health needs? And is exercise—the veritable polypill—always the answer? Link to the START trial: https://pubmed.ncbi.nlm.nih.gov/33591346/