Transfusion strategy for patients with acute brain injury, telehealth care, acute kidney injury after cardiac surgery, and weaning ventilatory support are the topics of 4 trials published in JAMA and presented at the 2024 European Society of Intensive Care Medicine meeting. JAMA Associate Editor Christopher Seymour, MD, MSc, joins Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS, to discuss.

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• Ventilator Weaning Strategies—Managing Interaction Between Randomized Treatments
• Restrictive vs Liberal Transfusion Strategy in Patients With Acute Brain Injury
• Effect of Tele-ICU on Clinical Outcomes of Critically Ill Patients
• Extracorporeal Blood Purification and Acute Kidney Injury in Cardiac Surgery
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