JACI: In Practice Deputy Editor Robert Zeiger describes the June issue, the theme of which is “Immunodeficiency”. Theme topics include the genetics, diagnosis, management, and complications of various types of inborn errors of immunity and related disorders. Dr. Zeiger then presents the Highlights of the Original Articles in the issue, which are on the topics of Immunodeficiency, Allergic Bronchopulmonary Aspergillosis, Asthma, Drug Allergy, and Food Allergy.