JACI: In Practice Editor-in-Chief, Michael Schatz, describes the June 2022 issue, the theme of which is “Chronic Rhinosinusitis.” Theme topics covered include epidemiology, assessment, and management of Chronic Rhinosinusitis; the interrelationships between Chronic Rhinosinusitis and COVID-19; and various aspects of biological treatment of Chronic Rhinosinusitis with nasal polyps. Dr. Schatz then presents the Highlights of the Original Articles in the issue, which are on the topics of rhinosinusitis, anaphylaxis, asthma, cough, eosinophilic disorders, food allergy, immunodeficiency, and immunotherapy. Access JACI: In Practice’s entire library: https://www.jaci-inpractice.org