JACI: In Practice Deputy Editor, Robert Zeiger, describes the February 2021 issue, the theme of which is “Immunodeficiency.” Theme topics covered include phenotypic, genomic, and immunological analyses; hematopoietic cell transplantation; immune immaturity and virus infections; and the overlap between primary immune deficiency and autoimmunity. Dr. Zeiger then presents the Highlights of the Original Articles in the issue, which are on the topics of COVID-19, Immunodeficiency, Anaphylaxis, Asthma, Drug Allergy, Eosinophilic Disorders, and Urticaria and Angioedema. Read the issue: https://bit.ly/JAIPFeb2021. Access JACI: In Practice’s entire library: https://www.jaci-inpractice.org