Ron Demuth has done almost everything you can do in biotech: bench scientist, academic administrator, CRO operator, private equity investor, VC, and now founder again at the frontier of physiomics. In this episode, we dig into what four decades of building actually teaches you: how to kill a project before it kills you, why lean-agile drug development is the only model that makes financial sense at scale, and the ten career rules Ron wishes he'd known at the start.

This is an episode about the operating philosophy underneath the science and why "get your hands dirty" is still the most underrated piece of advice in the industry.