On episode #105 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the weeks of 4/9 – 4/22/26.

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Links for this episode

• Viral
• Oral Nirmatrelvir–Ritonavir for Covid-19 in Higher-Risk Outpatients (NEJM)
• Same Pill, Different Impact — Reassessing the Efficacy of Nirmatrelvir–Ritonavir (NEJM)
• Paxlovid doesn't reduce hospitalization, death rates in vaccinated high-risk COVID outpatients, trial shows (CIDRAP)
• Risk of Guillain–Barré Syndrome after Laboratory-Confirmed Dengue Infection (NEJM)
• A New Type of Nonsuppressible Viremia Produced by HIV-Infected Macrophage (JID)
• First Report on Remdesivir Use for the Treatment of Respiratory Syncytial Virus in Five Allogeneic Hematopoietic Cell Transplant Recipients (JID)
• Bacterial
• Tetanus Surveillance — United States, 2009–2023 (CDC: MMWR)
• Notes from the Field: Tetanus in Four Children — Idaho, Minnesota, Missouri, and Wisconsin, 2024 (CDC: MMWR)
• Amoxicillin-Clavulanate vs Amoxicillin for Acute Sinusitis in Adults (JAMA)
• Efficacy and safety of vancomycin versus 13 alternatives in MRSA-confirmed skin and soft tissue infections: a meta-analysis of 39 randomized controlled trials (Infection)
• Methicillin-Resistant Staph Aureus (MRSA) Nasal Swab Utilization as a Predictor for MRSA Skin & Soft Tissue Infections: A Systematic Review and Meta-analysis (OFID)
• Practice variation, outcomes and definitions of suppressive antimicrobial therapy for prosthetic joint infections: a systematic review and expert consensus statement (CIC)
• Efficacy and safety of VPM1002 and Immuvacin preventing tuberculosis: phase 3 randomised clinical trial (PreVenTB trial) (BMJ)
• Comparison of Ceftolozane-Tazobactam and Ceftazidime-Avibactam in the Treatment of Multidrug-Resistant/Difficult-to-Treat Resistant Pseudomonas aeruginosa Infections: A Systematic Review and Meta-analysis (CID)
• Do C-Reactive Protein Measurements Predict Treatment Failure in Native Vertebral Osteomyelitis? (OFID)
• Fungal
• The Last of US Season 2 (YouTube)
• Rising burden of severe pediatric coccidioidomycosis: a 25-year single-center study (Journal of the Pediatric Infectious Diseases Society)
• Candida glabrata emerges as the most common cause of candidemia: analysis of a large hospital-based database, United States, 2016–2024 (CID)
• Test Performance and Clinical Utility of the cobas^® eplex Blood Culture Identification Fungal Pathogen Panel (OFID)
• Cutaneous Paraconiothyrium cyclothyrioides Infection in Lung Transplant Recipient, Georgia, USA (Emerging Infectious Diseases)
• Azole Resistance in Aspergillus fumigatus From Diverse Environments in Ohio, United States, Is Primarily Driven by TR₃₄/L98H and TR₄₆/Y121F/T289A Environmental Signatures (OFID)
• Parasitic
• Fatal Donor-Derived Disseminated Acanthamoeba Infection in a Liver Transplant Recipient (OFID)
• Miscellaneous
• Host–microbiome archetypes differentiate infection from pathogen carriage in the human lower airway (Nature Communications)

Music is by Ronald Jenkees

Information on this podcast should not be considered as medical advice.