Candidozyma auris has become one of the greatest environmental challenges facing infection prevention teams. Its ability to survive on surfaces, form resilient biofilms and spread within healthcare settings has raised important questions about whether our current cleaning and disinfection practices are enough.In this episode, Martin and Brett are joined by Aristotelis Papadimitriou from Athens to discuss his newly published systematic review on environmental decontamination of Candidozyma auris. They explore which disinfectants are the most effective, why biofilms change everything, the importance of fungal clades, and the significant gap between laboratory efficacy studies and the realities of cleaning busy healthcare environments.Open access paper we discuss:Papadimitriou A, Drosopoulou LP, Tseroni M, Kontopidou FV, Tsakris A, Vrioni G. Breaking the Chain of Infection: A Systematic Review of Environmental Decontamination of Candidozyma auris (2017-2025). J Fungi (Basel) 2026;12(2). https://doi.org/10.3390/jof12020131