In this amazing study, Dutch researchers used muscle biopsies in long COVID patients suffering from post-exertional malaise. They found that the muscle phenotype had changed, resulting in lower exercise capacity. They also found mitochondrial function issues and local amyloid accumulation. Macrophages and CD3+ T cells were also infiltrated in the muscle tissues.

The clinical takeaways are to keep inflammation under control, utilize light exercises and not stressful ones, and optimize mitochondrial health.

Let's review.

DrBeen: Medical Education Online

https://www.drbeen.com/

FLCCC | Front Line COVID-19 Critical Care Alliance

https://covid19criticalcare.com/

References (Jan. 11, 2024)

Muscle abnormalities worsen after post-exertional malaise in long COVID - Nature Communications

https://www.nature.com/articles/s41467-023-44432-3

A discovery in the muscles of long COVID patients may explain exercise troubles

https://www.npr.org/sections/health-shots/2024/01/09/1223077307/long-covid-exercise-post-exertional-malaise-mitochondria

Disclaimer:

This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only. Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.