Hump Day Hormones
Hump Day Hormones
Dr. Jill Jennings & Kortney Spann, APRN
Testosterone and Cardiovascular Risk and Breast Cancer Risk
26 minutes Posted Apr 29, 2026 at 5:00 am.
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26:25
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Show notes
“Does testosterone increase cancer risk?”
“Is it safe for my heart?”
“Will it make me gain weight?”
This is the episode where we take the most common fears around testosterone and go straight to the data.
Because there is a lot of confusion, and a lot of misinformation.
In this episode, we break down:
❤️ What current research shows about cardiovascular risk in physiologic dosing
🫀 Lipids, blood pressure, and metabolic markers in clinical trials
🎗️ What studies actually show about breast cancer risk and mammographic density
🧬 The difference between androgen receptor effects vs estrogen conversion in breast tissue
⚖️ Why dose and tissue context completely change outcomes
💪 How testosterone affects muscle mass, fat distribution, and insulin sensitivity
📉 What we know about body composition changes in women on therapy
We also talk about one of the most important distinctions:
Physiologic dosing is not the same as supraphysiologic exposure.
Most side effects and risks seen in practice are related to dosing, not the hormone itself.
And when used appropriately, the data we have so far does not show increased short-term risk for cardiovascular disease or breast cancer in women studied.
But we are also honest about the limitations:
Most trials are short term, and long-term data is still evolving.
Finally, we cover weight and metabolism:
Testosterone is not a weight loss drug.
But it does play a meaningful role in:
Lean muscle mass
Insulin sensitivity
Energy and activity levels
Which can indirectly support healthier body composition over time.
This episode is about clarity, not fear.
And helping you understand what the science actually says versus what people assume.