Dr. Alex Marson, MD, PhD, is a Senior Investigator at the Gladstone Institutes and a professor of medicine at the University of California, San Francisco. We discuss the biology of the immune system and cancer, and everyday choices that can increase or decrease your cancer risk, several of which are surprising but all of which are actionable. We also discuss immunotherapy, including how engineered T-cells can be used to defeat childhood and adult cancers. Dr. Marson explains CRISPR and gene editing to cure diseases, and we address the ethical questions surrounding gene editing in embryos, children and adults. This discussion is for anyone interested in avoiding cancer and/or seeking to understand the science and practical applications of immune- or gene-therapy. Read the show notes at hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman BetterHelp: https://betterhelp.com/huberman Helix Sleep: https://helixsleep.com/huberman LMNT: https://drinklmnt.com/huberman Function: https://functionhealth.com/huberman Timestamps

Alex Marson

Diseases & Current Biological Landscape; AI & Computational Tools

Immune System, Innate vs Adaptive Immune System

Thymus, T Cell Selection; B Cells & Antibodies

Sponsors: BetterHelp & Helix Sleep

Immune System Health, Sleep, Diet; Genes

Childhood Exposure & Allergy Prevention; Autoimmune Reactions

Whole Body Immune Response, Cytokines & Fever; Antibiotics

Cancer; Mutations & Cell Regulation; Smoking, BRCA Mutations, Sunlight

BRAC Mutations, Mutagens, Pesticides

Sponsor: AG1

X-Rays & Airport Scanners, Carcinogen vs Mutagen, Charred Meat, Food Dye

Immune-Based Cancer Treatment, Checkpoint Inhibitors, CAR T-Cell Therapy

CRISPR, Immunotherapies

Age & Cancer Risk; CAR T-Cells, Targets & Side Effects; Ketogenic Diet

CRISPR Discovery & Mechanism

CRISPR Precision, Risk & Benefit; CRISPR Technology Evolution

Sponsor: LMNT

CRISPR Cell Delivery, Clinical Trials; Treating Early Cancers & Prevention

Liposomes, Engineered Viruses, Lipid Nanoparticles (LNPs), Vaccines

COVID Pandemic & Trust in Science, mRNA Vaccine

Sponsor: Function

Drug Delivery to Cancer, Immunotoxins, T-Cell Engagers; AI Protein Targets

CRISPR Embryo Modification, Ethics; Heritable Gene Editing, Diversity

Deep Sequencing Embryos, Diversity; Overcoming Adversity & Resilience

Upcoming Therapeutics, Autoimmunity & CAR T-Cells, CRISPR & Gene Function

Banking T Cells or iPSCs?, Future of Cell Programming