Huberman Lab
Huberman Lab
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Improve Energy & Longevity by Optimizing Mitochondria | Dr. Martin Picard
3 hour 16 minutes Posted Dec 15, 2025 at 9:00 am.
Dr. Martin Picard, PhD, is a professor of behavioral medicine at Columbia University and an expert on how our behaviors and psychology shape cellular energy production and rates of aging. He explains that your mitochondria don’t just “make energy”; they translate what you do—your mindset and your relationships—into the energy you experience as vitality or lack thereof. He explains how exercise, nutrition, sleep, meditation, and even certain thought patterns and our sense of purpose can charge our cells like batteries. He also shares findings that hair greying is the result of cellular stress and is reversible. This episode links physical and mental ‘energy’ with cellular energy and provides science-supported tools to improve your physical and mental health. Read the episode show notes at hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman Helix: https://helixsleep.com/huberman Lingo: https://hellolingo.com/huberman Function: https://functionhealth.com/huberman Waking Up: https://wakingup.com/huberman Timestamps
Martin Picard
What is Energy?, Energy Flow & Transformation
Energy, Vitality, Emotions, Sensory Perception
Sponsors: Helix Sleep & Lingo
“Mito-Centric” View of World, Mitochondrial Energy & Information Patterns
Organelles, Mitochondria & Energy Transformation; Maternal Genes
Mitotypes & Differentiation, Mitochondria as “Social Organisms”
Food & Dysfunctional Energy Transformation
Lifestyle Choices & Interests, Physiological Growth
Pregnancy, Amenorrhea; Illness & Tiredness
Sponsor: AG1
Energy Transformation & Distribution; Body’s Wisdom, Feeling Sick
Tool: Feel Your Energy; Breath & Energy
Flow of Energy; Trade-Offs, Life Purpose & Enjoyment
Biology, Meaningful Experiences & Energy Flow
Sponsor: Function
Inflammation, Energetic Flow
Child Prodigies, Species Lifespan & Mitochondrial Metabolism; Aging
Lifestyle & Aging: Exercise, Fasting; Inflammation, Sleep, Stimulants
Energetic Stress Signals, GDF-15, Cancer, Heart Failure
Genes, Lifestyle & Aging
Gray Hair Reversal, Stress; Inflammation & Aging
Energy Recovery, Sleep & Mitochondrial Function, Stress, Meditation
Tools: Yoga Nidra, NSDR; Pre-Sleep Relaxation, Energy & Restorative Sleep
Diet & Individualization, Clinical Trials; Mitochondria & Nutrition, Keto
Alcohol & Energy Budget; Stress
Exercise, Increase Mitochondria, Overtraining; Resistance & Growth
Sponsor: Waking Up
Supplements & Mitochondria Health, Deficiencies, SS31, Methylene Blue
Energy Flow & Experiences, Balance
Transform Through Resistance, Energetic Awareness, Connection
Food Overconsumption & Mitochondria Disruption; Tissues & Mitochondria
Mitochondrial Health Test; Tool: Ways to Increase Energy; Meditation
Peptides; Fertility Supplements, Urolithin A; Electromagnetic Fields
Acknowledgements
0:00
3:16:46
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Show notes
Dr. Martin Picard, PhD, is a professor of behavioral medicine at Columbia University and an expert on how our behaviors and psychology shape cellular energy production and rates of aging. He explains that your mitochondria don’t just “make energy”; they translate what you do—your mindset and your relationships—into the energy you experience as vitality or lack thereof. He explains how exercise, nutrition, sleep, meditation, and even certain thought patterns and our sense of purpose can charge our cells like batteries. He also shares findings that hair greying is the result of cellular stress and is reversible. This episode links physical and mental ‘energy’ with cellular energy and provides science-supported tools to improve your physical and mental health. Read the episode show notes at hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman Helix: https://helixsleep.com/huberman Lingo: https://hellolingo.com/huberman Function: https://functionhealth.com/huberman Waking Up: https://wakingup.com/huberman Timestamps (00:00:00) Martin Picard (00:03:50) What is Energy?, Energy Flow & Transformation (00:07:53) Energy, Vitality, Emotions, Sensory Perception (00:14:18) Sponsors: Helix Sleep & Lingo (00:17:19) “Mito-Centric” View of World, Mitochondrial Energy & Information Patterns (00:25:26) Organelles, Mitochondria & Energy Transformation; Maternal Genes (00:31:12) Mitotypes & Differentiation, Mitochondria as “Social Organisms” (00:36:52) Food & Dysfunctional Energy Transformation (00:40:02) Lifestyle Choices & Interests, Physiological Growth (00:46:39) Pregnancy, Amenorrhea; Illness & Tiredness (00:51:07) Sponsor: AG1 (00:52:29) Energy Transformation & Distribution; Body’s Wisdom, Feeling Sick (00:56:27) Tool: Feel Your Energy; Breath & Energy (01:02:31) Flow of Energy; Trade-Offs, Life Purpose & Enjoyment (01:10:15) Biology, Meaningful Experiences & Energy Flow (01:16:27) Sponsor: Function (00:18:15) Inflammation, Energetic Flow (01:20:43) Child Prodigies, Species Lifespan & Mitochondrial Metabolism; Aging (01:28:56) Lifestyle & Aging: Exercise, Fasting; Inflammation, Sleep, Stimulants (01:37:06) Energetic Stress Signals, GDF-15, Cancer, Heart Failure (01:42:18) Genes, Lifestyle & Aging (01:47:54) Gray Hair Reversal, Stress; Inflammation & Aging (01:57:37) Energy Recovery, Sleep & Mitochondrial Function, Stress, Meditation (02:05:16) Tools: Yoga Nidra, NSDR; Pre-Sleep Relaxation, Energy & Restorative Sleep (02:10:58) Diet & Individualization, Clinical Trials; Mitochondria & Nutrition, Keto (02:20:14) Alcohol & Energy Budget; Stress (02:25:02) Exercise, Increase Mitochondria, Overtraining; Resistance & Growth (02:33:06) Sponsor: Waking Up (02:34:41) Supplements & Mitochondria Health, Deficiencies, SS31, Methylene Blue (02:41:31) Energy Flow & Experiences, Balance (02:49:13) Transform Through Resistance, Energetic Awareness, Connection (02:56:05) Food Overconsumption & Mitochondria Disruption; Tissues & Mitochondria (03:01:02) Mitochondrial Health Test; Tool: Ways to Increase Energy; Meditation (03:06:10) Peptides; Fertility Supplements, Urolithin A; Electromagnetic Fields (03:12:16) Acknowledgements (03:14:15) Zero-Cost Support, YouTube, Spotify & Apple Follow, Reviews & Feedback, Sponsors, Protocols Book, Social Media, Neural Network Newsletter Learn more about your ad choices. Visit megaphone.fm/adchoices🧬 DOWNLOAD THE PDF SUMMARY:Don't miss the specific dosages and timing protocols discussed today. Get the full visual guide and supplement breakdown here:👇https://goo.su/VOTEbVerified Science Resources.