In this episode of HSS Presents, rheumatologist Dr. Caroline Siegel is joined by HSS colleagues Dr. Lisa Sammaritano and Dr. Jane Salmon to discuss managing pregnancy for patients with autoimmune rheumatic diseases. They emphasize that most patients have successful pregnancies, but conditions like systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS) carry greater risks, including preeclampsia and placental insufficiency. Successful outcomes rely on preconception planning, which includes achieving quiescent disease for about six months on pregnancy-compatible medications and screening for antibodies. Dr. Salmon also shares exciting clinical trial results using a TNF inhibitor to improve pregnancy outcomes in high-risk APS patients.