AI-Powered Longevity Science — One Gene to Reverse Aging? | Daniel Ives PhD from Health Longevity Secrets

Health Longevity Secrets

Robert Lufkin MD

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AI-Powered Longevity Science — One Gene to Reverse Aging? | Daniel Ives PhD

1 hour 25 minutes Posted Apr 28, 2026 at 10:00 am.

— Centuries of experiments in a year 02:03 — Daniel's journey: physics → Aubrey de Grey 10:08 — The epigenetic clock breakthrough 12:09 — The 13 mitochondrial genes 20:09 — Yamanaka factors (OSKM) explained 22:10 — Partial reprogramm...

A DeLorean For Biology

Meet Daniel Ives And Shift

From Hallmarks To Data First

What Aging Means Without Mechanisms

Mitochondrial DNA Hypothesis Meets Clocks

Partial Reprogramming And Its Tradeoffs

Single Cell Clocks And Virtual Cells

Single Genes That Beat OSK

Targets For Translation Fibrosis And Hearing

Right To Try And Future Guardrails

When He Nearly Quit

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What if an AI could run centuries of aging experiments in a year? Dr. Daniel Ives, CEO of Shift Bioscience, explains how his team used a virtual cell to discover SB000 — a single gene that matches Yamanaka factor rejuvenation without cancer risk. CHAPTERS:

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