Health Longevity Secrets
Health Longevity Secrets
Robert Lufkin MD
What If Sugar Wasn't Sweet?
44 minutes Posted Nov 18, 2025 at 12:00 pm.
From Diagnostics To Metabolic Mission
Why Metabolic Health Shapes Lifespan
Sugar As The Modern Pandemic
The Glucose Roller Coaster And Cravings
Sweetness, Dopamine, And Hidden Sugar
Targeting Sweet Taste Receptors
Blocking Sweetness In The Gut
Sweeteners, Insulin, And CGM Evidence
Comparing To GLP‑1s And Behavior
How And When To Use NOSU
Natural Compounds And Safety
Happiness, Healthspan, And mTOR
Big Food, Systems Change, And Hope
Where To Find NOSU And Sander
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Show notes
Cravings aren’t just about weak will; they’re biology doing exactly what billions of food dollars engineered them to do. We sit down with Sander Brus to unpack how sweetness hijacks reward circuits, why kids are showing up with adult metabolic diseases, and what happens when you flip the switch on sweet taste itself. Sander takes us from his diagnostics background into the heart of metabolic health, explaining how sweet taste receptors (T1R2/T1R3) live on the tongue and in the gut, where the...