In this episode of HeadWise™, host Lindsay Weitzel, PhD, is joined by Amelia Barrett, MD to explore how emerging research on biological pathways may help explain why some people experience treatment-resistant migraine.The conversation focuses on several actionable pathways involved in medication metabolism, methylation, and neurotransmitter function, and discusses how these processes may influence migraine, medication side effects, and treatment response. Dr. Barrett also explains how nutrition, genetics, and personalized medicine may work together to support more individualized migraine care as research continues to evolve.This episode is for educational purposes only and is not intended to provide medical advice. Please consult your healthcare provider regarding your individual symptoms and treatment options.