HDBuzzCast

Exclusive HDBuzz interview with Prof Lesley Jones (Cardiff University) and Prof Sarah Tabrizi (University College London) about their new paper describing a 'genetic modifier' for Huntington's disease.

Jeff and Ed present a live recording of their 'ask the scientists anything' session from the 2016 HDSA Convention. Apologies for the less-than-perfect audio quality - we hope you agree the science Q&A makes up for it!

Jeff and Ed present a live recording of their 2016 research update at the 2016 Huntington's Disease Society of America Convention in Baltimore, entitled "The Best Time to Plant a Tree", including updates on the Teva Pride-HD and Legato studies, Pfizer's Amaryllis study, and Ionis Pharmaceuticals' HTTRx 'gene silencing' trial.

A special edition presenting the audio recording of Jeff Carroll and Ed Wild's Research Forum presentation at the Huntington's Disease Society of America Annual Convention in Dallas in June 2015 - entitled 'Get Behind the Bus'. Big reasons to have hope, and the latest from drug research and clinical trials across the world.

Dr Jeff Carroll and Dr Ed Wild select their personal highlights from the 2015 HD Therapeutics Conference in February, including encouraging updates on several 'flavors' of gene silencing drug, and new ways of sharing hot-off-the-press data. Plus, we highlight some ways of finding out what trials you can volunteer for, and suggestions of what to do if you're keen but not suitable for any trials right now. Websites we mention: http://chdifoundation.org (CHDI Foundation) - https://www.hdinhd.org (HD in HD) - http://hdsa.org (HD Society of America) - http://enroll-hd.org (ENROLL-HD).

Dr Jeff Carroll and Dr Ed Wild discuss the two large clinical trials (CREST-E and 2CARE) that were both recently halted early after 'futility' analyses. What does this mean for nutritional supplements in HD, and what hope is left for future clinical trials? (Spoiler alert: it's lots!) Plus, we discuss how to volunteer for trials, and lift the lid on the secret of our bespoke HDBuzzCast music (shout out to Philip Venables - http://philipvenables.com).

Welcome to HDBuzzCast, the official podcast of HDBuzz! In this inaugural episode, Dr Ed Wild and Dr Jeff Carroll introduce HDBuzzCast and talk about the five new clinical trials enrolling now or starting soon for Huntington's disease. Plus, a detailed discussion of the eagerly-awaited clinical trial of the first 'huntingtin lowering' drug to be tested in Huntington's diease. Called HTT-Rx, the drug is an antisense oligonucleotide developed by Isis Pharmaceuticals Inc. If you have questions about any aspect of HD research, send them to [email protected].

Introducing HDBuzzCast, the official podcast of HDBuzz. Huntington’s disease research news, in plain language. The first full episode will be released in a couple of weeks! Subscribe at http://hdbuzz.net/podcast