E.J. Gold's Shakti! The Spiritual Science of DNA outlines a system for achieving spiritual growth through mastery of the body and mind. The book uses the analogy of flute playing to illustrate the learning process, emphasizing deep understanding over daily acquisition of new facts. It details "Moving Meditations," a series of physical exercises and accompanying meditative practices designed to overcome ingrained fears and reactions, ultimately freeing the "Being" from the limitations of the "animal" (the body's automatic survival systems).

The core concept involves the manipulation of the "Bardo" states-periods between physical lives- through the understanding and conscious control of DNA modules, enabling a transition to a state of pure Being. Finally, the text introduces DNA communication, a method of interacting directly with the individual's genetic code to achieve spiritual transformation.