Fundamental Health with Paul Saladino, MD
Fundamental Health with Paul Saladino, MD
Paul Saladino, MD
Throughout my training and practice as a physician I have come to one very disappointing conclusion: Western medicine isn’t helping people lead better lives. Now that I’ve realized this, I’ve become obsessed with understanding what makes us healthy or ill. I want to live the best life I can and I want to be able to share this knowledge with others so that they can do the same. This podcast is the result of my relentless search to understand the roots of chronic disease. If you want to know how to live the most radical life possible I hope you’ll join me on this journey.
Controversial Thoughts: The COVID vaccine will not save you from the true pandemic!
Will an mRNA vaccine save us from COVID? Doubt it, and it certainly won’t save us from the massive amount of metabolic dysfunction that is driving severe COVID outcomes. In this Controversial Thoughts episode I describe recent research with both vaccines (Moderna/Pfizer), what looks good, things we still don’t know, and major potential problems possible in the future. How do you fix metabolic dysfunction? Listen until the end of the video in which I describe a striking interventional study with a carnivore-ish diet! #theremembering
Nov 27
29 min
Is it Saturated Fat or Polyunsaturated Fat (PUFA) that’s making you Fat and Unwell? Part 2 with Peter from Hyperlipid
This stuff is technical but critically important to understanding the possible underlying mechanisms by which excess PUFA may be hurting you. If this is confusing you may want to start with the first episode Peter and I did, all of which are at    Petro Dobromylskyj is a veterinarian, trained at the RVC, London University. He was fortunate enough to intercalate a BSc degree in physiology into his veterinary degree. He was even more fortunate to study under Patrick Wall at UCH, who set me on course to become a veterinary anaesthetist, mostly working on acute pain control. That led to the Certificate then Diploma in Veterinary Anaesthesia and enough publications to allow him to enter the European College of Veterinary Anaesthesia and Analgesia as a de facto founding member. Anaesthesia teaches you a lot. Basic science is combined with the occasional need to act rapidly. Wrong decisions can reward you with catastrophe in seconds. Thinking is mandatory. He stumbled onto nutrition completely by accident. Once you have been taught to think, it's hard to stop. Time Stamps:   0:14:04    Podcast Begins 0:14:46    Last Episode Recap 0:17:20    Why PUFAs drive obesity 0:22:43    Inappropriate insulin sensitivity 0:31:14    Why we have mitochondria 0:41:26    Being right on Q: shaping eukaryotic evolution 0:44:14    Mitochondrial satiety signaling 0:50:38    The glycerol phosphate shuttle 1:08:54    Reverse electron transport generating ROS 1:13:58    The Krebs cycle explained 1:22:59    Iatrogenic Hyperinsulinemia, Not Hyperglycemia, Drives Insulin Resistance in Type 1 Diabetes as Revealed by Comparison With GCK-MODY (MODY2) 1:23:58    Are carbs the root-cause of metabolic dysfunction? 1:30:31    Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase 1:38:47    Metformin (01) Insulin 1:44:29    Optimizing satiety with saturated fat and glucose 1:49:50    Where to Find Peter 1:50:34    The fates of Pyruvate 1:52:02    Diets could prevent many diseases 1:52:52    Metabolism and longevity: Is there a role for membrane fatty acids? Heart & Soil:    Cinder:,   Chilipad/ Ooler:   White Oak Pastures: code CarnivoreMD for 10% off first order   Belcampo: code CarnivoreMD for 20% off BluBlox:, code CarnivoreMD for 15 % off   Sacred Hunting:
Nov 23
1 hr 58 min
Controversial Thoughts - BONUS
If you missed yesterday's controversial thoughts podcast/video, you might also want to check that one out. I had a few ideas I wanted to discuss on COVID after I finished recording and knew I had to do another. The concept of "long COVID" is increasingly discussed today, but I'm not convinced this is anything new. First, it was "healthy" people (sadly) suffering from COVID who were obese or likely had metabolic dysfunction, and I think it's the same issue now. The majority of those with underlying metabolic dysfunction DON'T know they have it, which is why discussions of this are so important.   If you're new here and don't know what I mean by metabolic dysfunction, this might be thought of as insulin resistance, though that terminology is imprecise. Listen to the podcast next Tuesday (Fundamental Health) for part 2 with Peter from Hyperlipid to hear more discussion of this, or listen to the many podcasts I've done discussing it previously.   Take away: Long COVID is an underlying, undiagnosed metabolic illness IMO. Be metabolically healthy.#thremembering  
Nov 21
9 min
Controversial Thoughts: Why isn't the media talking about metabolic health? And Welcome to Hogwarts.
If you are curious about connections between metabolic dysfunction and the strength of your immune system but don't have time to listen to this video you disappoint me! 🤣 JK! But you should listen to this one and share it with someone in your life who is obese (and likely pre-diabetic) who doesn't think they are at risk of a bad COVID outcome, or maybe they are terrified but don't know what they can do about it other than cowering in their homes and continue eating junk. Nothing changes without a spark. Maybe you showing these ideas to someone will be the spark that saves their life. Or not, which is why I'll keep doing what I'm doing even amidst worsening censorship. Can't hold the truth down forever. #theremembering
Nov 20
26 min
Crucial COVID update with Ivor Cummins. Is the hysteria warranted?
This podcast will likely be censored on YouTube, but the video will be available at if this happens. We are only presenting facts in this podcast, but we’ll see what sort of nonsense the “fact checkers” come up with.  This is the second podcast I have done with Ivor on COVID. We’ve also done a podcast on LDL and cholesterol. All of these can be found under the “learn” tab at    Bio: Ivor Cummins BE(Chem) CEng MIEI PMP completed a Biochemical Engineering degree in 1990. He has since spent over 25 years in corporate technical leadership and management positions. His career specialty has been leading large worldwide teams in complex problem-solving activity.  Time Stamps   0:09:08   Podcast Begins 0:11:08   Ivor's predictions came true 0:12:32   The Mainstream covid messaging is missing the mark 0:14:58   Why lockdowns are ineffective 0:18:17   Do masks work? 0:19:51   The Who are science deniers 0:20:54   Do Lockdowns work? 0:25:28   This is a Case-demic, not a pandemic  0:26:08   Why PCR tests are bogus 0:37:07   The WHO redefines the word "pandemic" and positions themselves for profit 0:39:47   What about Sweden? 0:45:28   Herd immunity is the ONLY way forward 0:50:34   Effect of school closures on mortality from coronavirus disease 2019: old and new predictions 0:51:15   A country level analysis measuring the impact of government actions, country preparedness and socioeconomic factors on COVID-19 mortality and related health outcomes 1:04:07   Some thoughts on vaccines 1:13:49   We'll never conquer nature 1:15:42   The invisible blood of the "pandemic" nonsense 1:25:42   Is metabolic health a risk factor for covid-19 1:27:12   Is metabolic health a risk factor for covid-19DEAN 1:32:24   Metabolic Syndrome and COVID-19 Mortality Among Adult Black Patients in New Orleans 1:32:56   COVID-19: underlying metabolic health in the spotlight 1:45:12   The mainstream hypothesis that LDL cholesterol drives atherosclerosis may have been falsified by non-invasive imaging of coronary artery plaque burden and progression 1:46:35   The mainstream hypothesis on LDL is a complete farce 1:50:48   A 72-Year-Old Patient with Longstanding, Untreated Familial Hypercholesterolemia but no Coronary Artery Calcification: A Case Report 1:52:04   Macrophages of genetically characterized familial hypercholesterolemia patients show up‐regulation of LDL‐receptor‐related proteins 1:57:11   Where to find Ivor Heart & Soil:    Cinder:,   Chilipad/ Ooler:   White Oak Pastures: code CarnivoreMD for 10% off first order   Belcampo: code CarnivoreMD for 20% off BluBlox:, code CarnivoreMD for 15 % off
Nov 16
2 hr 1 min
Controversial Thoughts: Which Plants are Most/Least Toxic?
Last week’s Controversial Thoughts was on The Carnivore Diet for Beginners. This week, I wanted to discuss the spectrum of plant toxicity a bit more. Thinking about this from the perspective of plants makes it a whole lot easier. Plants don’t want their seeds (nuts, grains, seeds, legumes), leaves, stems, or roots eaten. Avoid these foods while focusing on the least toxic parts of plants (fruit- sweet and non-sweet) while making meat and organs the centerpiece of your diet and you will thrive. #theremembering
Nov 13
17 min
Is a Carnivore Diet The Real Paleo Diet?  Part 2, a friendly debate with Nora Gedgaudas.
Part 1 of “Is a Carnivore Diet the Real Paleo Diet” is my friendly debate with Loren Cordain et al., which can be found here. Nora Gedgaudas is a widely recognized expert on the “Paleo diet”. She is the author of the international best-selling book, Primal Body, Primal Mind: Beyond the Paleo Diet for Total Health and A Longer Life. She maintains a private practice in Portland, Oregon as both a Board-Certified nutritional consultant and a Board-Certified clinical Neurofeedback Specialist. Her latest book Primal Fat Burner was released in January 2017 by Simon & Schuster (Atria).   Time Stamps:   0:09:58   Podcast Begins 0:10:58   How Nora became a godmother of paleo 0:19:51   Why Primal? 0:24:49   Nora's time with the wolves 0:29:42   Humans are fat-eaters  0:32:28   Humans are designed to eat meat  0:38:34   Animal fat: the most precious nutrient 0:47:40   The protein sweet spot 0:52:22   Why you want cyclic mTOR activation 1:01:32   Prioritizing your digestive health 1:09:36   Dietary diversity does not equate to alpha diversity 1:14:49   Fiber is not required for a healthy gut 1:17:00   High fat or high protein? 1:27:52   Where to Find Nora Gedgaudas 1:29:38   Nora's Radical primitive skills Heart & Soil:    Cinder:,   Chilipad/ Ooler:   White Oak Pastures: code CarnivoreMD for 10% off first order Belcampo: code CarnivoreMD for 20% off
Nov 9
1 hr 36 min
Controversial Thoughts: The Carnivore Diet for Beginners
Most of my podcasts are pretty detailed and technical. I wanted to do a high level discussion of how to think about a Carnivore Diet and how to get started with this. There’s lots more info about this at on the about us page. The basics, eat well raised animal foods from nose to tail including organs and connective tissue. You can include less toxic plant foods if you’d like to depending on your goals. Welcome to #TheRemembering   Check out if you need more nose to tail nutrition in your life. The JRE show notes are there as well.  
Nov 6
13 min
How Seed Oils Destroy Your Mitochondria and Lead To Chronic Disease, with Tucker Goodrich
Tucker Goodrich is a technology executive in the financial industry who designs, runs, and debugs complex systems in high-risk environments. Areas of expertise include risk management, systems management, and cyber-security.    After experiencing some personal health crises and realizing that the ‘solutions’ offered by medical professionals weren’t working or addressing causation he started applying the same approach in research and evaluation of data to his own health issues to determine root causes.    His interests have focused on dietary and environmental drivers of chronic disease, including carbohydrate, wheat, and various classes of fats. Specifically, he's attempting to understand and popularize understanding of the mechanisms driving the diet-derived explosion in so-called chronic diseases (or diseases of civilization). He is active on twitter (@tuckergoodrich, has a blog called Yelling Stop, is an Expert Advisor for the nutrition start-up Nutrita, and has been a guest on numerous podcasts. Time Stamps: Podcast Youtube 0:09:38   0:03:21   Podcast Begins 0:11:12   0:04:55   What is Linoleic Acid? 0:16:44   0:10:27   How Linoleic acid caused disease 0:21:06   0:14:49   Understanding cardiolipin and the electron transport chain 0:23:28   0:17:11   Linoleic acid drives mitochondrial dysfunction, causes chronic illness 0:26:41   0:20:24   Maintenance of Cardiolipin and Crista Structure Requires Cooperative Functions of Mitochondrial Dynamics and Phospholipid Transport 0:32:56   0:26:39   Linoleic acid is uniquely damaging 0:35:30   0:29:13   Myths surrounding linoleic acid 0:38:19   0:32:02   The supremacy of animal fats 0:41:05   0:34:48   Brief episode of STZ-induced hyperglycemia produces cardiac abnormalities in rats fed a diet rich in n-6 PUFA 0:42:25   0:36:08   How seed oil consumption leads to necrosis and CVD 0:49:38   0:43:21   Mainstream understanding of PUFAs is built on faulty epidemiology 0:56:21   0:50:04   Circulating levels of linoleic acid and HDL-cholesterol are major determinants of 4-hydroxynonenal protein adducts in patients with heart failure 0:58:49   0:52:32   All about OxLAMs 1:03:32   0:57:15   Oxidized omega-6s are essential for atherosclerosis  1:13:33   1:07:16   Lowering dietary linoleic acid reduces bioactive oxidized linoleic acid metabolites in humans 1:14:30   1:08:13   Strong increase in hydroxy fatty acids derived from linoleic acid in human low density lipoproteins of atherosclerotic patients 1:15:38   1:09:21   The root cause of oxidative stress is linoleic acid 1:18:17   1:12:00   Metabolites of arachidonic acid and linoleic acid in early stages of non-alcoholic fatty liver disease—A pilot study 1:19:56   1:13:39   How Linoleic acid affects immunity 1:44:03   1:37:46   The linoleic acid-chronic illness hypothesis is air-tight 1:48:14   1:41:57   Calories In, Calories Out is the wrong paradigm 1:51:01   1:44:44   Role of Physiological Levels of 4-Hydroxynonenal on Adipocyte Biology: Implications for Obesity and Metabolic Syndrome 1:51:53   1:45:36   Eating seed oils is about as smart as eating poison ivy 1:54:54   1:48:37   Tucker Goodrich radical paleo evangelism 1:58:19   1:52:02   Where to find Tucker Goodrich Sponsors:   Heart & Soil:    Sacred Hunting:   Chilipad/ Ooler:   White Oak Pastures: code CarivoreMD for 10% off first order Belcampo: code CarnivoreMD for 20% off
Nov 2
2 hr 2 min
Controversial Thoughts: Why Epidemiology Is So Misleading and more on PUFA.
The number of ways that observational epidemiology is misinterpreted never ceases to amaze me. I wanted to make a video about this and truly explain in detail healthy user bias and unhealthy user bias, as well as why these two things can be such fatal confounders in this type of study. By contrasting epidemiology from the West and East, this becomes more apparent, and studies done on the UK cohort in this video illustrate that epidemiology seems to be telling us more about how beneficial healthy behaviors like exercise and avoiding alcohol and smoking are rather than eating meat vs vegetables. If you or someone you know has been misled by the mainstream reporting of epidemiology you need to watch and share this video!    Check out if you need more nose to tail nutrition in your life. The JRE show notes are there as well.  
Oct 30
35 min
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