Show notes
Hosted by Lester Nare and Krishna Choudhary, this one-episode special brings all three 2025 Nobel Prizes in the sciences into a single listen: Medicine (immune tolerance and FOXP3), Physics (macroscopic quantum tunneling in superconducting circuits), and Chemistry (metal–organic frameworks and “new rooms for chemistry”).
Summary
- Medicine: Regulatory T cells and the FOXP3 gene that prevent autoimmune disease.
- Physics: Macroscopic quantum tunneling and energy quantization in electrical circuits — the bridge to today’s qubits.
- Chemistry: Metal–Organic Frameworks (MOFs) — modular porous crystals enabling CO₂ capture, water harvesting, and hydrogen storage.
Show Notes
- Nobel Prize Press Release (2025 Medicine)
- Nature Genetics (2001) — FOXP3 mutation and IPEX link
- Nature Genetics (2001) — FOXP3 Mutation Causes Dysregulation
- Nature Genetics (2001) — FOXP3 Gene Cause IPEX Syndrome
- Science (2003) — FOXP3 function in regulatory T cells
- German Journal of Immunology (1995) — Sakaguchi’s first Treg paper
- Nobel Prize Press Release (2025 Physics)
- Physical Review Letters (1980s) — Macroscopic Quantum Tunneling Experiments (UC Berkeley)
- BCS Theory (1972 Nobel) — Bardeen, Cooper & Schrieffer, University of Illinois
- Josephson Effect (1973 Nobel) — Brian D. Josephson
- Google Quantum AI Lab — Quantum Supremacy Paper (Nature, 2019)
- Nobel Prize Press Release (2025 Chemistry)
- Nature (1999) — MOF-5 Discovery (Omar Yaghi et al.)
- Science (2003) — Reticular Chemistry Foundations
- Journal of the American Chemical Society (1989, 1990) — Richard Robson’s Early Frameworks
- Lawrence Berkeley National Laboratory — ChatMOF and AI-Assisted Materials Discovery