In this Journal Club edition of the EAU Podcast, Prof. Thomas Tailly leads a focused discussion on the recently completed APPEAL trial, a multicentre randomised controlled study evaluating whether routine antibiotic prophylaxis is necessary for patients undergoing extracorporeal shock wave lithotripsy (ESWL). The distinguished panel - Prof. Kari Tikkinen, Prof. Zafer Tandogdu, Dr. Daron Smith, and Dr. Guido Kamphuis - explores the study’s design, recruitment challenges, outcome measures and t...