EAN moderator: Anna K. Szewczyk (Lublin, Poland) Guest:Grazia Devigili (Milan, Italy)Anna K. Szewczyk and Grazia Devigili discuss Small fiber neuropathy (SFN), a broad group of conditions affecting small nerve fibers (Aδ or C). SFN is characterized by impaired pain and temperature sensation, as well as autonomic dysfunction. Its diagnosis and treatment are challenging, though recent findings on specific autoantibodies and ion channel polymorphisms offer new perspectives for understanding these forms and developing more targeted therapies.