In the ACOG committee opinion (743) on low-dose aspirin in pregnancy, the College states that more data is necessary before low-dose aspirin can be recommended for the prevention of spontaneous preterm birth. However, that was in 2018. Data since then (including data from January 2020 from the NIH) is supportive of aspirin use for the prevention of preterm birth. What does this data look like? In this episode we will review the possible indication of low-dose aspirin for the prevention of spontaneous preterm birth.